The nucleus isolation procedure was repeated twice, removing supernatant each time. Stimulation of cell proliferation and inhibition of gap junctional communication by linoleic acid. Prostate ; 8 : 75 The first ingredient on the label should be whole or sprouted grain flour, not white flour or unbleached white flour. However, the findings could also be accounted for by greater recall misclassification for more distant dietary intake, as pointed out by the authors. Previous studies have shown that increased dietary fat intake significantly alters the biological behaviours of prostate cancers driven by MYC 10, 11 suggesting this preclinical model as ideal to investigate the interplay between HFD, oncogene-driven metabolic vulnerabilities, and epigenetic alterations in prostate cancer progression. Woolf CM. Cases were men with lethal prostate cancer developed metastatic disease or died from prostate cancer and controls were men with indolent cancer those survived at least 8 years after prostate cancer diagnosis, without any evidence of metastases. Fresh VP tissues from week-old mice were dissociated to form a single cell suspension.
Credit: Getty Images. Saturated fat intake leads to cellular reprogramming associated with prostate cancer progression and lethality, according to new research. These findings could help in identifying patients at higher risk of a more aggressive, lethal disease. In addition, they suggest that dietary intervention involving the reduction of animal fat, and specifically saturated fat consumption in men with early-stage prostate cancer, could possibly diminish or delay the risk of disease progression. Some genes—called oncogenes—play a role in cancer initiation and progression. MYC is one of those. MYC is a key factor in tumorigenesis, i. Based on answers to validated food frequency questionnaires obtained from the Health Professionals Follow-Up Study and the Physician Health Study cohorts, researchers stratified prostate cancer patients based on their fat intake—high-fat diet vs. After integrating dietary and gene expression data from patients, the researchers discovered that animal fat and specifically saturated fat consumption mimicked a MYC overexpression. They validated their findings in vivo using a murine prostate cancer model.
One study 36 and a weak inverse correlation between monounsaturated fat consumption and prostate cancer incidence, whereas two other studies 34, 37 that adjusted diet energy intake found no association. Permissions Icon Permissions. A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Effect of a low-fat fat combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts. High Natl Cancer Inst cancer prostte : Note that caffeine acts as a diuretic, increasing water loss. Sies H, Stahl W. Cancer Cell.