Cleopatra S. Planeta 1. Drug addiction has serious health and social consequences. In the last two decades, new models have been proposed in an attempt to capture the more genuine aspects of addiction-like behaviors in laboratory animals. The goal of the present review is to provide an overview of the preclinical procedures used to study drug abuse and dependence and describe recent progress that has been made in studying more specific aspects of addictive behavior in animals. Drug addiction is an immense social challenge, not only because of its health-related consequences but also because of its socioeconomic and legal impact on society. Addiction is a human phenomenon that cannot be reproduced in a laboratory setting without unavoidable constraints. However, some of the behavioral characteristics of this syndrome can be satisfactorily modeled in laboratory animals. In this way, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors. However, the major goal of drug abuse research is to uncover the mechanisms of addiction; thus, in the last two decades, new models have been proposed in an attempt to capture the more genuine aspects of addiction-like behaviors in laboratory animals. The free-choice bottle model is a non-operant self-administration method restricted to the oral route of administration and most frequently used in alcohol addiction research.
The utility model relates to a kind of experimental provision, especially relates to a kind of experimental rat cage. Mouse is a mammal, because its full genome is high with human similarity, a lot of human diseasess can be simulated on experimental mouse, and mouse has, and reproduction speed is fast, survival is high, easily raisings, personality docility, grasp conveniently and the good characteristics of pharmaceutical agent assimilation effect, injection simultaneously is convenient, and volume is little, is convenient to transportation, but therefore mass rearing is widely used in scientific experiment. Experimental mouse is generally raised in mouse cage. At present, the experimental rat cage is generally used for feeding conventional solid diet experimental mouse, in some specific special requirements experiments, as can only give the experimental mouse semi-liquid diet time by the pharmaceutical properties requirement, then adopt the semi-liquid diet mouse cage, and existing semi-liquid diet is made up of cage body and the semi-liquid diet pipe that is installed in cage body one side with mouse cage. This mouse cage in use, the experimenter must pull out the semi-liquid diet pipe from the cage body, then the semi-liquid diet pipe is inverted, the rubber tube that connects by syringe is with in the semi-liquid diet ascending pipe, and the semi-liquid diet pipe that food will be housed after having injected is installed on the cage body once more. Like this, very inconvenient in actual mechanical process, not only spend plenty of time of experimenter, and semi-liquid diet Guan Jing is everlasting that plug damages easily in the cage body, simultaneously because semi-liquid diet pipe upper end is a hermetically-sealed construction, therefore easy cleaning not. The purpose of this utility model is to overcome above-mentioned deficiency of the prior art, a kind of mouse cage is provided, it is simple in structure, reasonable in design and use easy and simple to handle, can not only effectively solve to exist in the prior art and use inconvenient operation, spended time length, fragile semi-liquid diet pipe and clean inconvenient problem, dietary amount in simultaneously can timely clear and definite semi-liquid diet pipe is convenient to control and write down the diet of experimental mouse. For achieving the above object, the technical solution adopted in the utility model is: a kind of mouse cage, comprise cage body and the semi-liquid diet pipe that is installed in cage body one side, described semi-liquid diet pipe is the J-shaped structure, described semi-liquid diet pipe lower end and the socket connection of cage body, it is characterized in that: described semi-liquid diet pipe upper end is hatch frame, and described semi-liquid diet pipe upper end is provided with end cap, and described end cap and semi-liquid diet pipe flexibly connect. Above-mentioned a kind of mouse cage is characterized in that: described end cap and semi-liquid diet pipe box connect in succession.
Catalog No. Tightly cap the feeding tubes. Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens. Differential effects of alcohol drinking pattern on liver enzymes in men and women. Stage 3: acute administration of ethanol by oral gavage 9 h. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Animal studies of addictive behavior. The goal of the present review is to provide an overview of the preclinical procedures used to study drug abuse and dependence and describe recent progress that has been made in studying more specific aspects of addictive behavior in animals. Mouse diet is natural ingredient diet specifically for Show more.