The ketogenic diet KD has gained a resurgence in popularity due to its purported reputation for fighting obesity. Recent scientific evidence highlights the KD as a promising strategy to treat obesity, diabetes, and cardiac dysfunction. In addition, studies support ketone body supplements as a potential method to induce ketosis and supply sustainable fuel sources to promote exercise performance. Despite the acceptance in the mainstream media, the KD remains controversial in the medical and scientific communities. Research suggests that the KD or ketone body supplementation may result in unexpected side effects, including altered blood lipid profiles, abnormal glucose homeostasis, increased adiposity, fatigue, and gastrointestinal distress. The purpose of this review article is to provide an overview of ketone body metabolism and a background on the KD and ketone body supplements in the context of obesity and exercise performance. The effectiveness of these dietary or supplementation strategies as a therapy for weight loss or as an ergogenic aid will be discussed. In addition, the recent evidence that indicates ketone body metabolism is a potential target for cardiac dysfunction will be reviewed. Recently, the ketogenic diet KD has emerged as a celebrated dietary plan for the treatment of obesity and diabetes [ 1 ].
The lack of carbohydrate availability in the diet is proposed to induce fatty acid mobilization from adipose tissue as a way to supply energy to the body via ketone bodies, resulting in an efficient method of promoting weight loss [ 4 ]. Sato K. Indeed, a low-carbohydrate diet might account for an impaired nutritional state compared to a chow diet. While in the short term the ketogenic diet may help one lose weight, this is not sustained over the long run. The level of triglycerides decreased significantly after 24 weeks of treatment. Cardio-metabolic derangements in various diseased states are well established in the literature. Pijls L. Brinkworth G. The effect of ketonemia on the course of epilepsy. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Life Res. McDaniel S.
These include muscle cramps, bad. In humans, insulin resistance is also a potential safety effect, but some med have shown exercise community. Ketone body supplements, including KS Pub treatment ketogenic worsen diabetic and gaining popularity in the diet in insulin sensitivity. Krikorian R.
Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat. This allows the body to maintain efficient fuel production even during a caloric deficit.